Ethyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate monohydrate
نویسندگان
چکیده
There are three formula units in the asymmetric unit of the title compound, C(14)H(16)N(2)O(4)·H(2)O. Mol-ecules are linked by N-H⋯O hydrogen bonds into dimers with the common R(2) (2)(8) graph-set motif. Between dimers, single N-H⋯O hydrogen bonds are formed between the other N-H group of each pyrimidine ring and the hydroxyl groups. The water mol-ecules accept O-H⋯O hydrogen bonds from the hydroxyl groups and donate hydrogen bonds to the ester groups.
منابع مشابه
Ethyl 4-(4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate monohydrate
In the organic mol-ecule of the title compound, C(14)H(16)N(2)O(3)S·H(2)O, the two rings are oriented at a dihedral angle of 84.31 (2)°. In the crystal structure, intra-molecular O-H⋯O and inter-molecular O-H⋯O, N-H⋯O, O-H⋯S and N-H⋯S hydrogen bonds are found.
متن کاملMethyl 4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate monohydrate
In the title compound, C(15)H(18)N(2)O(5)·H(2)O, the pyrimidine ring adopts a flattened-boat conformation. The eth-oxy group attached to the benzene ring is in an extended conformation. The oxopyrimidine mol-ecules are linked into centrosymmetric R(2) (2)(20) dimers by O-H⋯O hydrogen bonds. The dimers are linked by N-H⋯O hydrogen bonds, forming a two-dimensional network parallel to the bc plane...
متن کاملEthyl 4-(3-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
In the title compound, C(14)H(15)BrN(2)O(3), the dihydro-pyrimidin-one ring adopts a boat conformation. In the crystal, adjacent mol-ecules are linked through N-H⋯O hydrogen bonds forming an R(2) (2)(8) ring motif and generating a zigzag chain extending in [010].
متن کاملEthyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
The title compound, C(14)H(16)N(2)O(3), belongs to a group of esters of 2-oxo- and 1,2,3,4-tetra-hydro-pyrimidine-5-carboxylic acids, which exhibit a wide spectrum of biological activities. The dihydro-pyrimidine ring adopts a screw-boat conformation. The crystal packing is stabilized by strong N-H⋯O and weak C-H⋯O inter-molecular hydrogen bonds. An intra-molecular C-H⋯O hydrogen bond is also p...
متن کاملEthyl 6-methyl-2-oxo-4-[4-(1H-tetrazol-5-yl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate–dimethylformamide–water (2/1/1)
The asymmetric unit of the title compound, 2C15H16N6O3·C3H7NO·H2O, contains two independent ethyl 6-methyl-2-oxo-4-[4-(1H-tetra-zol-5-yl)phen-yl]-1,2,3,4-tetra-hydro-pyrim-id-ine-5-carboxyl-ate mol-ecules, in which the dihedral angles between the tetra-zole and benzene rings are 20.54 (12) and 12.13 (12)°. An intra-molecular C-H⋯O hydrogen bond occurs in each mol-ecule. In the crystal, N-H⋯O, N...
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عنوان ژورنال:
دوره 65 شماره
صفحات -
تاریخ انتشار 2008